0000080220 00000 n Some TIAs exhibit strong pharmacological activities, whose production has beneficial effects on huma… 0000069849 00000 n 2016 Oct;54(10):2033-43. doi: 10.3109/13880209.2016.1140213. The Madagascar periwinkle (Catharanthus roseus in the family Apocynaceae) is an important medicinal plant and is the source of several widely marketed chemotherapeutic drugs. 0000082023 00000 n Muriel Le Roux, Françoise Guéritte, in Navelbine® and Taxotere®, 2017. Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. 0000112931 00000 n (e-mail: dr.g.madhumitha@gmail.com) Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic application of phenol red under UV@ 365 nm Aasaithambi Kalaiselvi1, Selvaraj Mohana Roopan2, Gunabalan Madhumitha2,*, 0000005059 00000 n International Journal of Crude Drug Research: Vol. 0000142557 00000 n Till date, arrays of reports are available on in vitro biotechnological improvements of C. roseus. 0000141901 00000 n Lee ON, Ak G, Zengin G, Cziáky Z, Jekő J, Rengasamy KRR, Park HY, Kim DH, Sivanesan I. Molecules. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of -cells of pancreas in diabetic rats. International Journal of Crude Drug Research: Vol. The C. roseus cell suspension culture A11 accumulates the terpenoid indole alkaloids strictosidine, ajmalicine and vindolinine. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. We observed that the metabolites are distributed heterogeneously in the petal, which is consistent with previous results reported for the C. roseus plant leaf and stem. The major challenge in the pharmaceutical industry is the low production rate of these Alkaloids. The content of ajmalicine reached 2.578 and 0.895 mg/g DW in callus and in cell suspension culture, respectively. Gr… 2019 Sep;103(18):7325-7354. doi: 10.1007/s00253-019-10035-6. •In vitro biotechnological interventions prompted major genetic advancements. 0000093706 00000 n 0000135334 00000 n 0000003953 00000 n 0000005022 00000 n 0000143872 00000 n 0000089169 00000 n Catharanthus roseus(L.) G. Don. Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, … 20.3.6 Catharanthus roseus (Apocynaceae) C. roseus (L.) G. Don (Apocynaceae), also known as Vinca rosea and originating from Madagascar, has now spread throughout Africa as a result of human activities. The genus Catharanthus is closely related to the genus Vinca and the species C. roseus was formerly known as Vinca rosea. 2009 Apr;52(Pt 4):313-23. doi: 10.1042/BA20080239. (1988). Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots (e.g., ajmalicine, reserpine, serpentine, horhammericine, tabersonine, leurosine, catharanthine, lochnerine, and vindoline). 2020 Oct 26;25(21):4945. doi: 10.3390/molecules25214945. 0000004198 00000 n Amongst these, two of the leaf-derived bisindole alkaloids—vinblastine and vincristine—are widely used in several anticancer chemotherapies. A white C. roseus flower Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae. 0000142294 00000 n 0000070245 00000 n The world's first comprehensive volume on Catharanthus roseus ; Includes research findings and review papers by world-renowned scientists from around the globe; Useful for a wide range of readers including plant scholars, scientists, researchers, graduate students, and botanists working on applications 0000072537 00000 n Extraction yield (µg per g dry of plant material) of catharanthine and vindoline from Catharanthus roseus with the different solvents. 279 120 11, 10 DECEMBER 2016 1811 *For correspondence. Remarkably, vinblastine and vincristine isolated from this plant … Phytochemical Composition, Antioxidant Capacity, and Enzyme Inhibitory Activity in Callus, Somaclonal Variant, and Normal Green Shoot Tissues of. Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. 0000139618 00000 n Expression of tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus hairy roots. Secondary metabolites are present in … 0000139876 00000 n Please enable it to take advantage of the complete set of features! 0000077163 00000 n Results show that C. roseus is highly preferred by the majority (60%) of the interviewed healers, and that the pink form is exclusively used to treat gonorrhoea. 0000071821 00000 n Studies on animal models have shown that ethanolic extracts of the leaves and flowers of C. roseus lower blood glucose levels [55]. 0000141471 00000 n The present review article concentrates chiefly on various biotechnological advancements based on plant tissue culture techniques of the last three decades, for instance, regeneration via direct and indirect organogenesis, somatic embryogenesis, secondary metabolite production, synthetic seed production, clonal fidelity assessment, polyploidization, genetic transformation, and nanotechnology. 0000070009 00000 n A proteomic approach is undertaken aiming at the identification of novel proteins involved in the alkaloid biosynthesis of Catharanthus roseus. COVID-19 is an emerging, rapidly evolving situation. 0000082459 00000 n 0000142760 00000 n 0000073677 00000 n 0000141096 00000 n Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae.It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat cancer. 0000082647 00000 n Catharanthus roseus, a model plant of the Apocynaceae family, is best known for production of the bis-indole monoterpene indole alkaloids (MIAs). Biotechnological interventions on the genus Rauvolfia: recent trends and imminent prospects. Rummun N, Rondeau P, Bourdon E, Pires E, McCullagh J, Claridge TDW, Bahorun T, Li WW, Neergheen VS. Pharmaceuticals (Basel). 2006 Aug;67(16):1758-64. doi: 10.1016/j.phytochem.2006.05.018. Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and vincristine. The concurrent incidence of extreme temperature and water shortage lead to temperature stress damage in plants. Nowadays, synthesis of metal NPs is an interesting area in nanoscience. 0000140778 00000 n 0000091382 00000 n It is also commonly grown for its ornamental values and, due to ease of infection and distinctiveness of symptoms, is often used as the host for studies on phytoplasmas, an important group of uncultivated … At pH 5.0, 1.7 mg of alkaloid/g dry weight was produced. RESEARCH ARTICLE Open Access Development of efficient catharanthus roseus regeneration and transformation system using agrobacterium tumefaciens and hypocotyls as explants Quan Wang†, Shihai Xing†, Qifang Pan, Fang Yuan, Jingya Zhao, Yuesheng Tian, Yu Chen, Guofeng Wang and Kexuan Tang* Cells were grown for 21 days, and alkaloid accumulation was monitored during this period. 0000142143 00000 n 2020 Oct 12;13(10):303. doi: 10.3390/ph13100303. 0000072477 00000 n It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. Two of its alkaloids, vincristine and vinblastine (possessing anticancerous properties), are being used copiously in pharmaceutical industries. Also, periwinkle is still the only source of these alkaloids and their precursors, catharanthine and vindoline. RESEARCH ARTICLES CURRENT SCIENCE, VOL. 0000071032 00000 n %PDF-1.4 %���� is a well known medicinal plant. 0000143590 00000 n 0000139741 00000 n 0000071189 00000 n Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Epub 2017 Nov 22. The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. In the present investigation, the leaf juice of C. roseus has been evaluated for its hypoglycemic activity in normal and alloxan-induced diabetic rabbits. ATP content increased in the leaves of C. roseus under UVB radiation. 0000074041 00000 n Catharanthus roseus (C. roseus) and ursolic acid (UA) are ayurvedic medicines with multiple pharmacological activities including antidiabetic activity, but till date, no study is available on their combination. 0000089222 00000 n The intricate networks of TIAs biosynthesis is regulated by all kinds of molecules such as plant signaling molecules (jasmonate acid, ethylene and nitric oxide), plant growth regulators, prenylated proteins and transcription factors. Rats were divided into six groups. 0000078855 00000 n World Journal of Pharmaceutical Research and Catharanthus roseus) Bougainvillea . Research article; Open Access; Published: 06 May 2016 Examining the transcriptional response of overexpressing anthranilate synthase in the hairy roots of an important medicinal plant Catharanthus roseus by RNA-seq. 0000069530 00000 n Keywords: Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. (1988). Catharanthus roseus is an important medicinal plant, which produces a variety of indole alkaloids of significant pharmaceutical relevance. Epub 2016 Mar 17. Anticancerous; Genetic transformation; Nanotechnology; Polyploidy; Secondary metabolite; Somatic embryogenesis. Email: benjamin.philmus@oregonstate.edu (B. P.) and megrawm@science.oregonstate. The complete mRNA sequence for the enzyme strictosidine synthase (SSS) was determined. 0000095484 00000 n Phytochemistry. Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots … Epub 2019 Jul 30. (e-mail: dr.g.madhumitha@gmail.com) Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic • This review provides an insight on in vitro-based research achievements till date. Global warming contributes to higher temperatures and reduces rainfall for most areas worldwide. 0000072215 00000 n 0000080887 00000 n 0000071425 00000 n Overview; Fingerprint; Abstract. A plastid‐localized bona fide geranylgeranyl diphosphate synthase plays a necessary role in monoterpene indole alkaloid biosynthesis in Catharanthus roseus Sarma Rajeev Kumar Molecular Plant Biology and Biotechnology Lab, CSIR‐Central Institute of Medicinal and Aromatic Plants, Research Centre, Bengaluru, 560065 India 0000004697 00000 n 0000073467 00000 n Ultraviolet (UV)-B radiation acts as an elicitor to enhance the production of secondary metabolites in medicinal plants. Vinblastine and vincristine are two important anti-cancer drugs that are synthesized by the Terpenoid Indole Alkaloids (TIAs) pathway in periwinkle (Catharanthus roseus).  |  It is popularly known as Madagascar periwinkle. The production of nanoparticles (NPs) for the manufacturing of new smart materials at the nanoscale with unique properties has rapidly increased in the past few years (Albrecht et al., 2006; Singh et al., 2016). 0000071268 00000 n Little Bright Eye) was achieved by HPLC-DAD-ESI-MS/MS. 0000080634 00000 n 0000139080 00000 n 0000140109 00000 n Catharanthus roseus leaves (10 g) frozen in liquid nitrogen and ground to a fine powder were extracted with 10 ml buffer [25 m m Tris pH 7.5, 100 m m NaCl, 1 m m DTT, 10% (v/v) glycerol, 5% (w/v) polyvinylpolypyrrolidone] and centrifuged at 16 000 g for 30 min. 0000004276 00000 n trailer 0000134812 00000 n 0000070087 00000 n hޤTkPTu?��܅x(���`fݽ�^"^� �����jX�4+4a߻�(�,�¬��TJ4�IY�"�,�/~�)'�)?5��s�"1S:�9���9�s����� b |Ph�����a6nb ��τbb���)R�~�7��}���K���3���Йڴ���d�ЁM����Z��h Ƣ6F�����A{}CS�J]c��cy\찭��rN�c�����z�)��-�[�>��uY���wT� !�Z��1)����Vz�����w�ڍ}�P�_�k�����;R^Z6l�X�V�=��x�������g;��Zv��^k��E�� ��~���y�4�C���i�G_y���o�e�;���ry�ïY�l���v��9(���!%�ѪU�"D?��eqym,g�h�ߠo�#. Benyammi R, Paris C, Khelifi-Slaoui M, Zaoui D, Belabbassi O, Bakiri N, Meriem Aci M, Harfi B, Malik S, Makhzoum A, Desobry S, Khelifi L. Pharm Biol. 0000139800 00000 n �9�ʯ��tyM�A�—�_��T�|��'��b�����IW�����ʽ����O �'ǭ]���ČCpQd�e��QYЍ�Aܼ�0���Qǝ!��*�ιy��x+� O����9t�m��FH��D&���tz�U9��t|Ѫ����8�`�_G[��C�=$�N��C �k���ºe#�b��D���㕯��C �,Q�I5�%#��ʡ��e�N��D�SG���P��I?�@:e� �v��C$���. C. roseus is a rich source of indole alkaloids. Catharanthus roseus L (apocyanaceae) also known as Vinca Rosea, is native to the Caribbean Basin and has historically been used to treat a wide assortment of diseases. Catharanthus roseus Linn (Apocynaceae), is a traditional medicinal plant used to control diabetes, in various regions of the world. Waleed M. Al-Shaqha 1 %%EOF 0000135441 00000 n Abstract. It also portrays the importance of various factors influencing the success of in vitro biotechnological interventions in Catharanthus and further addresses several shortcomings that can be further explored to create a platform for upcoming innovative approaches. 0000076142 00000 n 0000070324 00000 n Mukherjee E, Gantait S, Kundu S, Sarkar S, Bhattacharyya S. Appl Microbiol Biotechnol. 0000080814 00000 n Biotechnol Bioeng. Remarkably, vinblastine and vincristine isolated from this plant … 0000000016 00000 n startxref 0000004240 00000 n Four distinct transformed cell lines were obtained with A. tumefaciens strains A281, BO542, and A. rhizogenes strain K599, and selected on hormone-free medium. To secondary metabolites in medicinal plants [ 18 ] not available mg/g DW in callus and cell. And enzymatic profiling acid ( SA ) prospective research methodologies have been successfully incorporated into anticancer therapy [ ]... 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Concurrent incidence of extreme temperature and water shortage lead to secondary metabolites Catharanthus! 2009 Apr ; 52 ( Pt 4 ):313-23. doi: 10.3109/13880209.2016.1140213 extracts of leaf-derived... Inhibitory activity in callus, Somaclonal Variant, and Enzyme Inhibitory activity in normal and alloxan-induced diabetic rabbits the production... Expression of tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus under UVB radiation itself the! Cardioprotective activity etc quantities of pollution with wasted solvents till date roseus suspended.